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Mutations Aspergillus nidulans
This table list several mutations in the hmgA gene in A. nidulans (the homolog of the human HGO gene) causing loss of catalytic activity, that were identified during the characterization of suDfah mutations. (From: Rodríguez et al., 2000)
Allele |
Nucleotide change1 |
Mutation type |
Predicted mutant fungal HGO protein2 | Equivalece of mutated residue(s) to human HGO residue(s) |
hmgA2 | C1206G | Nonsense | 1® 302* | 1® 297* |
hmgA3 | 879insA | Frameshift | 1® 194fs | 1® 190fs |
hmgA5 | DG1657 | Frameshift | 1® 437fs | 1® 430fs |
hmgA6 | C1188G | Missense | His297Gln | His292 |
hmgA8 | G875C | Missense | Arg193Pro | Ser189 |
hmgA9 | G198T | Missense | Met1Ile | |
hmgA10 | C1315T | Missense | His340Tyr | His335 |
hmgA11 | DA523fs | Frameshift | 1® 94fs | 1® 86fs |
hmgA12 | D(A1414®C1416) | Deletion | D Ile373 | D Thr367 |
hmgA13 | A310T | Splicing | ? | |
hmgA14 | C238T | Nonsense | 1® 14* | 1® 5* |
hmgA15 | C504G | Nonsense | 1® 86* | 1® 78* |
hmgA16 | C1318G | Missense | Arg341Gly | Arg336 |
hmgA17 | G763C | Missense | Gly174Arg | Gly170 |
hmgA18 | G1647A | Nonsense | 1® 433* | 1® 426* |
hmgA19 | 393ins26nts | Frameshift | 1® 50fs | 1® 44fs |
hmgA20 | G816C | Splicing | ? | |
hmgA21 | D(G1473®G1569) | Deletion | D (Lys393®Ser408) | D (Ala387® Thr395) |
hmgA22 | T770G | Missense | Leu176Trp | Met172 |
hmgA23 | 609ins7nts | Frameshift | 1® 122fs | 1® 118fs |
hmgA24 | T743C | Missense | Leu167Pro | Leu163 |
hmgA25 | G264T | Splicing | ? |
1) Nucleotide 1 is the first base of the
published A. nidulans cDNA sequence: U30797.
2) Asterisk denotes an stop codon; fs
indicates mutant frameshifted amino acid sequence after the indicated wild type residue